C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/04 (2006.01) A61K 31/40 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/30 (2006.01) C07D 403/04 (2006.01) C07D 491/056 (2006.01)
Patent
CA 2093306
There are disclosed compounds having the formula <see formula I> wherein X is hydrogen, chloro, bromo, fluoro, hydroxy, loweralkoxy, arylloweralkoxy, acyloxy, loweralkylaminocarbonyloxy, diloweralkylaminocarbonyloxy, amino, loweralkylamino, diloweralkylamino, acylamino, loweralkyl or trifluoromethyl; Y is hydrogen, loweralkyl, chloro or bromo; Z is hydrogen, loweralkyl, loweralkoxy or halogen; or X and Z taken together can form a methylenedioxy group; R1 is hydrogen, loweralkyl, arylloweralkyl, carboxyloweralkyl, arylloweralkoxycarbonylloweralkyl or loweralkoxycarbonylloweralkyl; R2 is hydrogen, loweralkyl or hydroxyloweralkyl; R3 is hydrogen or loweralkyl; or R2 and R3 together with the carbon to which they are attached form (C3 - C7)cycloalkyl; R4 is hydrogen or loweralkyl; R5 is hydrogen, loweralkyl, aryl, arylloweralkyl, acyl, arylloweralkoxycarbonyl, loweralkoxycarbonyl or aryloxycarbonyl; R6 is hydrogen, chloro, bromo, arylcarbonyl, loweralkylcarbonyl, aryl(hydroxy)loweralkyl or hydroxyloweralkyl; and m and n are independently 0 to 5 with the proviso that the sum of m plus n is not greater than 5; and pharmaceutically acceptable addition salts thereof, or where applicable, the optical or geometrical isomers or racemic mixtures thereof, intermediates in the process for making the compounds, a process for making the compounds and pharmaceutical compositions and their use as neuroprotective agents.
Flanagan Denise Mary
Kosley Raymond W. Jr.
Martin Lawrence L.
Nemoto Peter A.
Aventis Pharmaceuticals Inc.
Bereskin & Parr
Hoechst-Roussel Pharmaceuticals Inc.
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