1-heteroaryl-4-¬(2,5-pyrrolidinedion-1-yl)alkyl|piperazine...

Details 1-heteroaryl-4-¬(2,5-pyrrolidinedion-1-yl)alkyl|piperazine... 1-heteroaryl-4-¬(2,5-pyrrolidinedion-1-yl)alkyl|piperazine...

C - Chemistry, Metallurgy

07

D

167/217, 260/259

C07D 401/14 (2006.01) C07C 51/56 (2006.01) C07C 57/58 (2006.01) C07C 61/39 (2006.01) C07D 207/40 (2006.01) C07D 209/96 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1285564

Abstract of the Disclosure Disubstituted N,N'-piperazinyl derivatives are disclosed wherein one substituent is heteroaryl and the other is alkylene attached to the ring nitrogen of substituted 2,5-pyrrolidinedion-1-yl moieties. The substitution pattern of the pyrrolidinedione ring involves either germinal disubstitution, including spiro ring fusion, or 3,4-phenyl ring fusion to give phthalimide derivatives. Heteroaryl substitution on the other piperazine nitrogen comprises pyridine, pyrimidine, and benzisothiazole ring systems. Representative examples of these compounds demonstrate useful central nervous system effects.

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