1-hydrocarbyloxyphenyl-1, 2-diphenylalkene derivatives

Details 1-hydrocarbyloxyphenyl-1, 2-diphenylalkene derivatives 1-hydrocarbyloxyphenyl-1, 2-diphenylalkene derivatives

C - Chemistry, Metallurgy

07

C

260/369, 260/626

C07C 43/20 (2006.01) C07C 43/196 (2006.01) C07C 43/215 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 43/235 (2006.01) C07D 303/22 (2006.01)

Patent

CA 1150290

ABSTRACT Triphenylalkene derivatives of the formula:- Image wherein R1 is alkenyl, cycloalkenyl, cycloalkenyl- alkyl, halogenoalkenyl, hydroxyalkyl, dihydroxyalkyl, hydroxycycloalkyl, dihydroxycycloalkyl, hydroxycycloalkyl- alkyl, epoxyalkyl, alkoxyalkyl or alkylthioalkyl each of up to 10 carbon atoms, wherein R2 is alkyl of up to 6 carbon atoms, halogen or nitro and wherein ring A may optionally bear a halogen substituent or an alkoxy substituent of up to 4 carbon atoms. These compounds possess antioestrogenic activity and are useful in the treatment of anovulatory infertility and of breast tumours. Representative of the compounds is 1-p- allyloxyphenyl-trans-1,2-diphenylbut-2-ene. There are also disclosed processes for the manufacture of the compounds and pharmaceutical compositions containing them.

352045

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