1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2h,4h-[1,3]- oxazino-...

Details 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2h,4h-[1,3]- oxazino-... 1-(hydroxymethyl)-1,6,7,11b-tetrahydro-2h,4h-[1,3]- oxazino-...

C - Chemistry, Metallurgy

07

D

167/211, 260/244

C07D 498/04 (2006.01) A61K 31/535 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1288100

Abstract The invention relates to 1-(hydroxymethyl)- -1,6,7,11b-tetrahydro-2H,4H-[1,3]oxazino- or -thiazino- [4,3-a]isoquinoline derivatives of the formula (I), Image (I) wherein R1 and R2 are alkoxy havlng from 1 to 6 carbon atoms, X is oxygen or sulfur, Y is =O, =S or an =NR3 group, wherein R3 is hydrogen, alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms or optionally substituted phenyl, and acid addition and quaternary salts thereof, which show vasodilatory, antispasm and antidiarrhoeic activity.

477213

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