1-indolylalkyl-4-(substituted-pyridinyl)piperazines

Details 1-indolylalkyl-4-(substituted-pyridinyl)piperazines 1-indolylalkyl-4-(substituted-pyridinyl)piperazines

C - Chemistry, Metallurgy

07

D

167/211, 260/266

C07D 401/14 (2006.01) A61K 31/495 (2006.01) C07D 401/12 (2006.01) C07D 487/08 (2006.01)

Patent

CA 1337421

A series of 1,4-disubstituted piperazine derivatives comprised of indol-3-ylalkyl and substituted pyridin-2-yl substituent groups. These compounds are useful as anti- depressant agents. The compounds more particularly are of the formula Image wherein R1 and R2 are independently selected from hydrogen and lower alkyl, wherein lower means C1-4; R3, R4, R8 and R9 are independently selected from hydrogen, lower alkyl, lower alkoxy, carboxamide, halogen, trifluoromethyl and thio-lower alkyl, with the proviso that R8 and R9 cannot both be hydrogen at the same time; A is a C5-7 cycloalkanyl or cycloalkenyl ring, or A is Image wherein n is an integer from 1 to 3 and R5 is the same as R1; and R6 and R7 are independently selected from hydrogen, methyl or R6 and R7 can be taken together as a methylene bridge.

601179

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