1-isopropylamino-3-(4'-(2-alkoxycarbonyl-aminoethoxy)-phenox...

Details 1-isopropylamino-3-(4'-(2-alkoxycarbonyl-aminoethoxy)-phenox... 1-isopropylamino-3-(4'-(2-alkoxycarbonyl-aminoethoxy)-phenox...

C - Chemistry, Metallurgy

07

D

260/468.8

C07D 303/24 (2006.01) C07C 271/16 (2006.01)

Patent

CA 1048526

ABSTRACT The invention relates to new amines of the formula I: Image (I) wherein R is methyl or ethyl, as well as a process for their preparation. The new compounds have valuable pharmacological properties. Thus, they block cardial .beta.-receptors, which is shown at the determination of the antagonism of tachy- cardy after an intravenous injection of 0.5 µg/kg of d/1-isoproterenol sulphate on an anaesthetized cat at an intravenous dose of 0.002 to 2 mg/kg. Thus, they block the vascular .beta.-receptors, which is shown at the determination of the antagonism of vascodilation after an intravenous injection of 0.5 µg/kg of d/l-isoproterenol sulphate on an anaesthetized cat at an intravenous dose of 3 mg/kg or more. The new compounds can be used as cardioselective antagonists of adrenergic .beta.-receptor-stimulators e.g. at the treatment of arrhythmias and angina pectoris. One may also use them as valuable intermediates at the pre- paration of other useful compounds, especially pharmaceutically active com- pounds.

218830

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