1-methyl-2-(phenyl-oxymethyl)-5-nitroimidazoles

C - Chemistry – Metallurgy – 07 – D

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260/305, 260/392

C07D 233/64 (2006.01)

Patent

CA 1073917

ABSTRACT OF THE DISCLOSURE This invention is directed to new 1-methyl-2-(phenyl- oxymethyl)-5-nitro-imidazoles of the formula I IMG> (I) wherein R1, R2 and R3 can be identical or different and represent hydrogen, straight-chain or branched alkyl having from 1 to 4 carbon atoms, or wherein R1 and R2 as alkylene chain, together with the nitrogen and carbon atom of the amidino group, are con- stituents of a pyrrolidine, piperidine or hexamethylene-imine ring, or wherein R2 and R3 as alkylene chain together with the nitrogen atom of the ammidino group, are constituents of a pyrrolidine, ppiperidine, morpholine or thiomorphiline ring, and the salts thereof with physiologically tolerable acids; and to a process for their preperation. The new compounds are suitable for the treatment of protozoal diseases.

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