1-(methylated piperidino (and pyrrolidin...

Details 1-(methylated piperidino (and pyrrolidin... 1-(methylated piperidino (and pyrrolidin...

C - Chemistry, Metallurgy

07

D

260/291.1, 260/2

C07D 207/08 (2006.01) C07D 211/22 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1046066

ABSTRACT OF THE DISCLOSURE 1-[Methylated piperidino (and pyrrolidin-1-yl)]-3- substituted phenoxy)-2-propanols of the formula: Image wherein R is a 2-thienylmethyl group, a 2-pyridylmethyl group, a 2- pyridyl group, a tetrahydrofurfuryloxy group, a furfuryloxy group, a 2-thienylmethoxy group, A 2-pyridyloxy group or a group of tbe formula R5-X-A-O- wherein R5 is a lower alkyl group, X is -O-, -S- or -SO2-, and A is a lower alkylene group or a -CH2-C-C-CH2- group, R1 is a hydrogen atom, a lower alkyl group or a halogen atom, R2, R3 and R4 are each a hydrogen atom or a methyl group, and n is zero or 1, and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof are disclosed. They exhibit antiarrhythmic action, local anaesthetic action, analgesic action and gastric juice secretion inhibiting action.

207061

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