1-methylcarbapenem derivatives, their preparation and their...

C - Chemistry – Metallurgy – 07 – D

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C07D 477/00 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2070305

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) wherein: R1 is hydrogen or an unsubstituted or substituted alkyl group; and A represents a number of cyclic or acyclic nitrogen-containing groups are valuable antibiotics which are resistant to dehydropeptidase I in vivo. Methods of preparing the compounds and of using them are also disclosed.

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