1-n-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of...

Details 1-n-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of... 1-n-(.alpha.-hydroxy-.omega.-aminoalkanoyl) derivatives of...

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/22 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1058170

ABSTRACT OF THE DISCLOSURE Compounds of the formula (I): - Image (I) wherein A is a hydrogen atom or methyl group, and n is an integer of 1-4, inclusive, are prepared by selective acylation of the 1-amino group of an otherwise amino-protected derivative of 3'-deoxykanamycin A with an .alpha.-hydroxy-.omega.-amino acid, with subsequent substitution of the amino-protecting groups to yield the desired compounds. The novel compounds, semisynthetic derivatives of kanamycin A, are useful for the therapeutic treatment of various infections caused by gram- negative and gram-positive bacteria, including certain strains which are drug-resistant.

250636

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