1-(n-phenylaminoalkyl)-piperazine derivatives substituted at...

Details 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at... 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at...

C - Chemistry, Metallurgy

07

D

C07D 295/12 (2006.01) A61K 31/495 (2006.01) C07D 209/08 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 241/24 (2006.01) C07D 295/13 (2006.01) C07D 295/22 (2006.01) C07D 295/24 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2297095

1-(N-phenylaminoalkyl)-piperazine derivatives of formula (I), (R = H, alkyl- CO, cycloalkyl-CO, substituted cycloalkyl-CO or monocyclic heteroaryl-CO; R1 = H or lower alkyl; R2 = halogen, alkoxy, phenoxy, NO2, CN, acyl, NH2, NH(acyl), alkyl-SO2NH, alkoxycarbonyl, NH2CO, (alkyl)NHCO, (alkyl)2NCO, (acyl)NHCO, CF3 or polyfluoroalkoxy; B = benzyl or mono- or bicyclic aryl or heteroaryl, all optionally substituted) bind to 5HT1A receptors and are useful for the treatment of neuromuscular dysfunctions of the lower urinary tract. The use of these compounds for the preparation of a medicament for this treatment is claimed, and some of the compounds (with restricted B values) are claimed per se.

L'invention concerne des dérivés de 1-(N-phénylaminoalkyl)-pipérazine qui correspondent à la formule (I) (R=H, alkyl-CO, cycloalkyl-CO, cycloalkyl-CO substitué ou hétéroaryl-CO monocyclique; R¿1?=H ou alkyle inférieur; R¿2?=halogène, alcoxy, phénoxy, NO¿2?, CN, acyle, NH¿2?, NH(acyle), alkyl-SO¿2?NH, alcoxycarbonyle, NH¿2?CO, (alkyl)NHCO, (alkyl)¿2?NCO, (acyl)NHCO, CF¿3? ou polyfluoroalcoxy; B = benzyle ou hétéroaryle ou aryle mono- ou bicyclique, tous éventuellement substitués). Ces dérivés se lient aux récepteurs 5HT¿1A?, et sont utiles lors du traitement de dysfonctionnements neuro-musculaires des voies urinaires inférieures. Cette invention concerne également l'utilisation de ces composés dans la préparation d'un médicament utilisé pour ce traitement, ainsi que certains de ces composés dont la valeur B est réduite.

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