1-nitrogen containing-7-hydroxy-indone derivatives and salts...

Details 1-nitrogen containing-7-hydroxy-indone derivatives and salts... 1-nitrogen containing-7-hydroxy-indone derivatives and salts...

C - Chemistry, Metallurgy

07

C

167/179, 260/542

C07C 49/755 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 49/747 (2006.01) C07D 295/26 (2006.01)

Patent

CA 1245663

ABSTRACT OF THE DISCLOSURE Indane derivatives and their salts represented by the general formula (1), Image (1) wherein R1 is an amino group which may have lower alkyl groups as the substituents, a hydroxylimino group, an alkanoylamino group having 1 to 10 carbon atoms which may have halogen atoms as the substituents, a lower alkylsulfonylamino group, a phenylsulfonylamino group which may have lower alkyl groups as the substituents on the phenyl ring, a benzoylamino group having lower alkyl groups as the substituents on the phenyl ring, and a phenyl-lower alkylamino group having a hydroxyl groups or a lower alkyl groups as the substituents on the phenyl ring, R2 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, an amino group, an amino- lower alkyl group, a lower alkanoylamino group, a lower alkanoylamino-lower alkyl group which may have halogen atoms as the substituents, a lower alkylthio group, a 1-piperidinesulfonyl gorup, or a lower alkenyl group; R3 is a hydrogen atom, a lower alkyl group, or a halogen atom; R4 and R5 are the same or different from each other, and are each a hydrogen atom, or a lower alkyl group; provided that when R1 is a hydroxylimino group, then R2 and R3 should not be hydrogen atoms at the same time. The indane derivatives and their salts are useful as preventive and curative agents for various diseases and disorders caused by the excessive forma- tion and accumulation of the active oxygen radicals and the peroxidized substances in the living body, and/or the defects of phylaxis mechanisms of the living body, for example anti-arreriosclerotic agents, carcinogenesis preventive agents, carcinostatic agents, anti-inflam- matory agents, analgesics, autoimmune disease curative agents, platelets aggregation inhibitory agents, hypotensive agents, anti-hyperlipemic agents, retinosis of immature infant and cataract preventive and curative agents. The indane derivatives and their salts are also useful as antioxidants for oils and fats being contained in processed foods.

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