1-oxa-2-oxo-3-r-3-aza-5-z-cyclopentane derivative

Details 1-oxa-2-oxo-3-r-3-aza-5-z-cyclopentane derivative 1-oxa-2-oxo-3-r-3-aza-5-z-cyclopentane derivative

C - Chemistry, Metallurgy

07

D

167/235, 260/304

C07D 263/24 (2006.01) A61K 31/42 (2006.01) C07D 413/02 (2006.01) C07D 413/06 (2006.01)

Patent

CA 1286677

1-Oxa-2-oxo-3-R-3-aza-5-Z-cyclopentane derivatives A B S T R A C T The invention relates to new 1-oxa-2-oxo-3-R-3-aza-5-Z- cyclopentane derivatives, having the following formula: Image wherein R is alkyl or hydroxyalkyl having in each case 1-6 C atoms, cycloalkyl having 3-8 C atoms, unsubstituted aryl or aralkyl or aryl or aralkyl each of which has a total of 6-15 C atoms and, in the aryl radical, is monosubstituted to trisubstituted by alkyl, alkoxy, OH and/or Cl or monosubstituted by methylenedioxy, Z is -(CHOH)n-H and n is 2, 3, 4 or 5, and which can be used as intermediate products for the preparation of active compounds for medicaments, such as toloxatone.

513944

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