1-oxa-3-aza-dibenzoazulenes as inhibitors of tumour necrosis...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/04 (2006.01) A61K 31/42 (2006.01) C07D 263/52 (2006.01)

Patent

CA 2481463

The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-.alpha. (TNF-.alpha.) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

La présente invention se rapporte à des dérivés de la classe des 1-oxa-3-aza-dibenzoazulènes, à leurs sels et solvates pharmaceutiquement acceptables, à des procédés et intermédiaires de préparation de ces derniers, à leurs effets anti-inflammatoires, en particulier à l'inhibition de la production du facteur de nécrose tumorale .alpha. (TNF-.alpha.) et à l'inhibition de la production d'interleukine 1 (IL-1), et à leurs effets analgésiques.

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