C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/10 (2006.01) A61K 31/438 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2741839
Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I wherein Ar1, Ar2, R1, R2, R3 and R4 are as defined herein and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.
La présente invention concerne des 1-oxa-8-azaspiro[4.5]décane-8-carboxamides de formule I où Ar1, Ar2, R1, R2, R3 et R4 sont tels que définis dans la présente invention, ainsi que les sels de qualité pharmaceutique de tels composés, pouvant être employés dans le traitement de pathologies ou d'états pathologiques associés à l'activité de l'hydrolase des amides d'acide gras (FAAH), les états pathologiques incluant la douleur aiguë, la douleur chronique, la douleur névropathique, la douleur nociceptive, la douleur inflammatoire, la fibromyalgie, la polyarthrite rhumatoïde, l'affection abdominale inflammatoire, le lupus, le diabète, l'asthme allergique, l'inflammation vasculaire, l'incontinence urinaire, la vessie hyperactive, les vomissements, les troubles cognitifs, l'anxiété, la dépression, les troubles du sommeil, les troubles de l'alimentation, les troubles locomoteurs, le glaucome, le psoriasis, la sclérose en plaques, les troubles vasculaires cérébraux, les lésions cérébrales, les troubles gastro-intestinaux, lhypertension ou les maladies cardio-vasculaires.
Long Scott Allen
Meyers Marvin Jay
Pelc Matthew James
Schweitzer Barbara Ann
Thorarensen Atli
Pfizer Inc.
Torys Llp
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