1-oxa-dibenzoazulenes as inhibitors of tumor necrosis factor...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 493/04 (2006.01) A61K 31/55 (2006.01) C07D 307/00 (2006.01) C07D 313/00 (2006.01)

Patent

CA 2485214

The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-cc (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

L'invention concerne des dérivés de 1-oxa-dibenzoazulène, les solvates et les sels pharmacologiquement acceptables de ces dérivés, des procédés et des intermédiaires pour la préparation de ces dérivés ainsi que les effets anti-inflammatoires qu'ils exercent, en particulier pour inhiber la production du facteur .alpha. de nécrose des tumeurs (TNF-.alpha.) et celle de l'interleukine 1 (IL-1), de même que l'action analgésique de ces dérivés.

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