1-oxadethiacepham compounds

C - Chemistry – Metallurgy – 07 – D

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260/244.2

C07D 498/04 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1099715

1-Oxadethiacepham Compounds ABSTRACT Intermediates for preparing an antibacterial 1-dethia-1-oxa- cephalosporins which are represented by the following formula: Image (wherein R is a monovalent group deducted the carbonyl from an acyl derived from a carboxylic or carbonic acid; Y1 is a divalent group of the following formula: Image , Image , Image , Image or Image (in which COB is carboxy or protected carboxy; X is hydrogen or a nucleophilic group; and Z is a leaving group) are prepared from a compound of the following formula: Image (wherein R and Y1 are as defined above) by the action of an acid. The new compounds of this invention shown by the following formula: Image (wherein A is amino or substituted amino; E is hydrogen or methoxy; and Y is a divalent group of the following formula: Image , Image , Image , or Image (in which COB, X, and Z are as defined above) are convertible into other compounds of the same formula by apply- ing conventional methods in .beta.-lactam chemistry.

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