1-oxo-1h-pyrimido[6,1-b]benzthiazole derivatives

Details 1-oxo-1h-pyrimido[6,1-b]benzthiazole derivatives 1-oxo-1h-pyrimido[6,1-b]benzthiazole derivatives

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 513/04 (2006.01) C07D 239/557 (2006.01) C07D 513/14 (2006.01)

Patent

CA 1103666

ABSTRACT OF THE DISCLOSURE New l-oxo-lH-pyrimido[6,1-b]benzthiazole derivatives and their process of preparation of formula (I) are provided - Image wherein R1, R2, R3 and R4, which may be the same or different, are selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, trifluoromethyl and straight-chain or branched-chain lower alkyl, alkoxy or alkylthio radicals, or R2 and R3 can together represent an alkylenedioxy radical, and X is a hydroxyl group or lower alkoxy or tetrazolyl-5- amino radical, and the pharmaceutically acceptable, pharmacologically compatible salts thereof, the new derivatives when administered parenterally or perorally display anti- allergic action and are useful for combating allergic diseases, for example, allergic asthma, hay-fever and urticiria; further the new derivatives possess anti-oedematous and anti-inflammatory properties.

322968

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