C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/46 (2006.01) A61K 31/4035 (2006.01) A61P 25/16 (2006.01)
Patent
CA 2645426
Compounds of Formula (I) or (Il) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
La présente invention concerne des composés pouvant être employés dans le traitement de l'amyotrophie spinale ainsi que dans d'autres applications, de même que des méthodes d'utilisation de tels composés pour augmenter l'expression de SMN, augmenter l'expression de EAAT2 ou augmenter l'expression d'un acide nucléique qui code pour un codon stop traductionnel introduit par mutation ou déphasage.
Barnes Keith D.
Fairfax David
Heemskerk Jill
Johnson Graham
Johnson Matthew Robert
Albany Molecular Research Inc.
Department Of Health And Human Services Government Of The United States Of America Represented By The Se
Ridout & Maybee Llp
Science Applications International Corporation (saic)
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