1-phenethyl-.alpha.-phenyl-piperidine-3-propane-nitrile...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/34 (2006.01) A61K 31/445 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/60 (2006.01) C07D 317/64 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1239406

- 41 - ABSTRACT 1-PHENETHYL-.alpha.-PHENYL-PIPERIDINE-3-PROPANE-NITRILE DERIVATIVE Compounds of the formula: Image wherein R1, R2, R3, R4 and R5 each represent a hydrogen atom, a halogen atom, a (C1-4)alkoxy radical, a (C1-4)alkylthio radical, a halogeno(C1-4)alkyl radical, a (C1-4)alkyl radical or a cycloalkyl-alkoxy-alkoxy radical or two of the adjacent R symbols together form a methylenedioxy or ethylenedioxy radical, R6 represents a hydrogen atom, a (C1-4)alkyl radical, a (C3-6)cycloalkyl radical or a (C3-6)cycloalkyl-(C1-4)alkyl radical, and R7, R8 and R9 each represent a hydrogen atom or a-methoxy radical, are new compounds possessing pharmacological properties; they are useful as calcium antagonists and as antihypertensives.

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