C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/283, 260/277
C07D 215/22 (2006.01) A61K 31/47 (2006.01) C07D 215/233 (2006.01) C07D 405/12 (2006.01)
Patent
CA 1286673
ABSTRACT OF THE DISCLOSURE: The invention relates to novel decahydroquinolinol derivatives represented by the general formula: Image and pharmaceutically acceptable acid addition salts thereof, in which X represents oxygen or sulphur, R represents an alkyl radical having from 1 to 3 carbon atoms, R1 represents fluorine, chlorine, bromine or methoxy, R2 represents hydrogen or methoxy or R1 and R2, when they are taken together, represent a 2,3-methylenedioxy or 3,4-methylene- dioxy radical. These derivatives are inhibitors of calcium translocation at the level of the cell membrane and are useful more particularly in the treatment of pathological syndromes of the cardiovascular system such as, for instance, angina pectoris.
483817
de Claviere Michel
Polster Peter
Prost Maurice
de Claviere Michel
Polster Peter
Prost Maurice
Robic
Sanofi
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