C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279, 260/306
C07D 209/42 (2006.01) C07D 401/12 (2006.01) C07D 491/056 (2006.01)
Patent
CA 1189859
ABSTRACT New 1-phenyl-2-aminocarbonylindole compounds are described which have the general formula I Image I where R1 is a hydrogen atom, or a lower alkyl, alkenyl, cycloalkyl or cycloalkylalkyl radical, R2 is a hydrogen atom or a lower alkyl radical, R3 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, R4 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, or, if R3 is a hydrogen atom, R4 may be a nitro or trifluoromethyl radical, or R3 and R4 together denote a methylenedioxy or ethylenedioxy radical, R5 has the meanings given for R3, R6 has the meanings given for R4, R7 is a hydrogen atom or, if R5 and R6 are lower alkoxy radicals, R7 may also be a lower alkoxy radical, R8 and R9 are each a hydrogen atom or a lower alkyl radical or, together with the nitrogen atom, form a heterocyclic group, and Z is an alkylene chain whlch is optionally substituted by hydroxyl. The compounds have pharmacological properties, in particular antiarrhythmic properties. The compounds may be in the form of the free bases or acid addition salts. Pharmaceutical compositions containing these compounds are described as is a method of preparing them. Valuable intermediates for the production of these compounds and methods of preparing the intermediates are also described.
409061
Buschmann Gerd
Kaupmann Wilhelm
Kuhl Ulrich
Magda Stephen J.
Ohlendorf Heinrich-Wilhelm
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Solvay Pharmaceuticals Gmbh
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