1-phenyl-3-azabicyclo[3.1.1]heptane-2,4 diones, the use...

Details 1-phenyl-3-azabicyclo[3.1.1]heptane-2,4 diones, the use... 1-phenyl-3-azabicyclo[3.1.1]heptane-2,4 diones, the use...

C - Chemistry, Metallurgy

07

D

167/228, 260/281

C07D 221/22 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1280418

Substituted l-phenyl-3-azabicyclo[3.1.1]heptane-2,4 diones, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds Abstract l-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula (I) Image in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic- aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.

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