1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors

Details 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors

C - Chemistry, Metallurgy

07

C

C07C 49/84 (2006.01) A61K 31/12 (2006.01) A61K 31/135 (2006.01) C07C 45/29 (2006.01) C07C 45/45 (2006.01) C07C 49/794 (2006.01) C07C 49/796 (2006.01) C07C 49/813 (2006.01) C07C 217/76 (2006.01) C07C 225/22 (2006.01)

Patent

CA 2051501

This invention relates to 1-phenyl-3-phenyl-2-propyne- 1-ones of the formula: Image wherein: R1, R2 and R3 are each independently hydrogen; C1-C6 alkyl; C1-C6 alkoxy; halogen; -N(Y1)(Y2), wherein Y1 and Y2 are each independently hydrogen or C1-C6 alkyl; or X2-(Ar)-(CH2)n-O-, wherein Ar is phenyl or naphthyl, n=0 or 1, X=C1-C6 alkoxy or -N(Y1)(Y2), wherein Y1 and Y2 are as previously defined and Z=0, 1, 2; or a pharmaceutically acceptable salt thereof, and the use of these compounds as calcium uptake inhibitors in leuko- cytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.

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