1-phenyl-4-(1-¬2-aryl|cyclopropyl) methylpiperazines:...

Details 1-phenyl-4-(1-¬2-aryl|cyclopropyl) methylpiperazines:... 1-phenyl-4-(1-¬2-aryl|cyclopropyl) methylpiperazines:...

C - Chemistry, Metallurgy

07

D

C07D 295/06 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 295/02 (2006.01) C07D 295/03 (2006.01) C07D 295/073 (2006.01) C07D 295/12 (2006.01) C07D 295/135 (2006.01)

Patent

CA 2359989

Disclosed are compounds of formula (I) or pharmaceutically acceptable addition salts thereof wherein: R1, R2, R3, R4 and R5, R6, R7 and R8 represent organic and/or inorganic substituents as defined herein, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

La présente invention concerne des composés représentés par la formule (I) ou des sels d'addition acceptables du point de vue pharmaceutique desdits composés. Dans ladite formule, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7? et R¿8? représentent des substituants organiques et/ou inorganiques définis dans la description. Lesdits composés sont utiles dans le traitement et/ou la prévention de troubles neuropsychologiques, dont, entre autres, la schizophrénie, la manie, la démence, la dépression, l'anxiété, les comportements compulsifs, l'abus de substances toxiques, les troubles moteurs apparentés à la maladie de Parkinson et les troubles du mouvement liés à l'utilisation d'agents neuroleptiques.

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