1-phenyl-4-benzylpiperazines: dopamine receptor subtype...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/10 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 295/06 (2006.01) C07D 295/073 (2006.01) C07D 295/096 (2006.01) C07D 295/112 (2006.01) C07D 295/135 (2006.01)

Patent

CA 2279620

Disclosed are compounds of formula (I) or the pharmaceutically acceptable addition salts thereof wherein: R1 is halogen or C1-C4 alkyl; and R2 and R3 are the same or different and represent hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, alkylthio, hydroxy, amino, mono(C1-C4)alkylamino, di(C1-C4)alkylamino, or R2 and R3 together represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are dopamine D4(ant)agonists and useful in the treatment of neuropsychological diseases such as schizophrenia, psychotic depression and mania.

L'invention concerne des composés représentés par la formule (I) ou leurs sels d'apport acceptables sur le plan pharmaceutique, dans laquelle: R1 représente halogène ou alkyle C1-C4; R2 et R3 sont semblables ou différents et représentent hydrogène, halogène, alkyle C1-C4, alkoxy C1-C4, alkylthio, hydroxy, amino, mono-alkylamino C1-C4, di-alkylamino C1-C4; R3 et R4 représentent ensemble une fraction d'alkénylène à quatre atomes de carbone, constituant, avec le noyau phényle auquel ils sont fixés, une fraction naphtyle. Ces composés sont des (ant)agonistes de D4 de dopamine et sont utiles pour le traitement de maladies neuro-psychologiques, telles que la schizophrénie, la dépression psychotique et la manie.

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