1-phenyl-containing substituent-4-amino-pyrimidine compounds

Details 1-phenyl-containing substituent-4-amino-pyrimidine compounds 1-phenyl-containing substituent-4-amino-pyrimidine compounds

C - Chemistry, Metallurgy

07

D

260/292.2, 260/2

C07D 211/58 (2006.01) C07D 401/04 (2006.01)

Patent

CA 1246081

ISOINDOLE DERIVATIVES, PREPARATION, AND USES Abstract of the Disclosure Novel phthalimide intermediates are reduced to 5-sulfamoyl-6-halo-3-oxoisoindole compounds bearing a sub- stituted 1-phenylalkyl-4-piperidinyl moiety as the isoin- dole N-substitutent. Preferred compounds such as 6-chloro- 2,3-dihydro-3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-1H- isoindole-5-sulfonamide exhibit diuretic and antihyperten- sive properties.

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