1-phenyl-containing substituent-4-animo-pyrimidinyl...

Details 1-phenyl-containing substituent-4-animo-pyrimidinyl... 1-phenyl-containing substituent-4-animo-pyrimidinyl...

C - Chemistry, Metallurgy

07

D

167/231, 260/277

C07D 401/04 (2006.01) A61K 31/445 (2006.01) C07D 211/58 (2006.01)

Patent

CA 1268767

MJ 566 Abstract of the Disclosure Novel phthalimide intermediates are reduced to 5-sulfamoyl-6-halo-3-oxoisoindole compounds bearing a sub- stituted 1-phenylalkyl-4-piperidinyl moiety as the isoin- dole N-substitutent. Preferred compounds such as 6-chloro- 2,3-dihydro-3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-1H- isoindole-5-sulfonamide exhibit diuretic and antihyperten- sive properties.

583066

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