1-phenylalkyl-3-phenylurea derivative

Details 1-phenylalkyl-3-phenylurea derivative 1-phenylalkyl-3-phenylurea derivative

C - Chemistry, Metallurgy

07

D

167/243, 167/265

C07D 317/48 (2006.01) A61K 31/17 (2006.01) A61K 31/335 (2006.01) C07C 275/28 (2006.01) C07C 335/16 (2006.01) C07D 317/58 (2006.01) C07D 319/18 (2006.01) C07D 321/10 (2006.01)

Patent

CA 2034673

- 94 - Abstract of the Disclosure A novel 1-phenylalkyl-3-phenylurea derivative represented by the following formula (I): Image (I) wherein R1 and R6 represent independently hydrogen, C1-C5 alkyl, C1-C5 alkoxyl or halo; R2 represents hydrogen or C1-C15 alkyl; R3 represents C1-C15 alkyl or R3 represents together with R2 C2-C9 alkylene; R4 and R5 represent independently C1-C5 alkyl, C1-C5 alkoxyl or halo; X represents oxygen or sulfur; Y represents -O-(CH2),?-0- wherein ? is an integer of 1 to 3 or -(CH2)p- wherein p is an integer of 3 to 5; m is 0 or an integer of 1 to 5; and n is 0 or an integer of 1 to 3, is provided. The l-phenylalkyl-3-phenylurea derivative (I) have the action of reducing cholesterol in blood by ACAT inhibition, and therefore, useful for treating hyperlipemia and atherosclerosis.

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