1-phenylpyrrole compounds

Details 1-phenylpyrrole compounds 1-phenylpyrrole compounds

C - Chemistry, Metallurgy

07

D

C07D 207/335 (2006.01) A61K 31/405 (2006.01) A61P 5/42 (2006.01) A61P 7/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2736930

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1 -C3 alkyl group; R2 represents a hydroxy -C1 -C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1 -C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like,- R5 represents a sulfamoyl group or a C1-C3 alkylsulf onyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.

La présente invention concerne un composé destiné au traitement prophylactique et/ou thérapeutique de maladies cardio-vasculaires, de la néphropathie, de la fibrose, de laldostéronisme primaire ou de l'dème. Le composé correspond à la formule générale (I) suivante : où R1 représente un groupement alkyle en C1-C3 ; R2 représente un groupement hydroxyalkyle en C1-C4, etc. ; R3 représente un groupement halogéno, un groupement halogénoalkyle en C1-C3, etc. ; R4 représente un atome d'hydrogène, un groupement halogéno, etc. ; R5 représente un groupement sulfamoyle ou un groupement (alkyle en C1-C3)-sulfonyle ; R6 représente un atome d'hydrogène, un groupement halogéno, etc., ou un N-oxide, un atropoisomère de ce composé, ou l'un de leurs sels de qualité pharmaceutique.

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