1-phenylsulphonyl-1,3-dihydro-2h-indol-2-one derivatives,...

Details 1-phenylsulphonyl-1,3-dihydro-2h-indol-2-one derivatives,... 1-phenylsulphonyl-1,3-dihydro-2h-indol-2-one derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 13/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2450437

The invention concerns compounds of formula (I), as well as their addition salts with acids or organic salts, their solvates and/or hydrate(s), exhibiting affinity and selectivity for arginine-vasopressin V¿1b? receptors and/or for ocytocin receptors, and further, for certain compounds an affinity for V¿1a? receptors. The invention also concerns the method for preparing them, intermediate compounds of formula (IV) useful for their preparation, pharmaceutical compositions containing them and their use for preparing medicines.

L'invention concerne des composés de formule (1),ainsi que leurs sels avec des acides ou organiques, leurs et/ou leur hydrates, présentant une affinité et une sélectivité pour les récepteurs V¿1b? de l'arginine-vasopressine et/ou pour les récepteurs de l'ocytocine et, de plus, pour certains composés une affinité pour les récepteurs V¿la?. L'invention conceme également leur procédé de préparation, les composés intermédiaires de formule (IV) utiles pour leur préparation, les compositions pharmaceutiques les contenant et leur utilisation pour la préparation de médicaments.

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