1-piperazinecarboxamide derivatives

Details 1-piperazinecarboxamide derivatives 1-piperazinecarboxamide derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/246

C07D 241/04 (2006.01) C07D 295/073 (2006.01) C07D 295/20 (2006.01) C07D 295/205 (2006.01) C07D 295/21 (2006.01) C07D 295/215 (2006.01) C07D 317/28 (2006.01) C07D 401/06 (2006.01)

Patent

CA 1253148

ABSTRACT 1-piperazinecarboxamide derivatives are described which have the formula (I) Image (I) wherein R1 is a member selected from hydrogen, halogen or trifluoromethyl; wherein X is selected from: ? CO (Ia) ? CHOH (Ib) ?CHOR8 (Ib') ?CHOCOR8 (Ib") ? CH2 (Ic) ? C = CR6R7 (Id) ? CH - CHR6R7 (Ie) Image (If) wherein R2 and R3 are the same or different and selected from hydrogen or lower alkyl; wherein Z is either oxygen or sulfur; wherein Y is -NR4R5, where R4 and R5 are the same or different and selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aryl-(lower alkyl), or R4 and R5 may together with the N-atom form a 5- or 6- or 7-membered saturated ring, where one of the carbon atoms may be exchanged for O, NR8 or NCOR8; wherein R6 and R7 are the same or different and selected from hydrogen or lower alkyl; wherein R8 is lower alkyl or lower alkenyl; with the provisio that when X is?CO, then R4 is hydrogen and R5 is different from hydrogen. Pharmaceutical compositions containing said 1-piperazine- carboxamide derivatives are also described. The derivatives are useful in treating mental disorders and/or aggression in man and in treating aggression in animals and for calming animals. Different processes for preparing the derivatives are also described.

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