1-piperazinocarboxylates, process for their preparation and...

Details 1-piperazinocarboxylates, process for their preparation and... 1-piperazinocarboxylates, process for their preparation and...

C - Chemistry, Metallurgy

07

D

260/267.5, 260/2

C07D 241/04 (2006.01) C07D 295/20 (2006.01) C07D 295/205 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1228070

ABSTRACT Diphenylbutyl-1-piperazinocarboxylates of the formula Image I wherein R is alkyl straight or branch chained having from 1 to 1.0 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, aralkyl having from 7 to 9 carbon atoms or phenyl unsubstituted or substituted by one to three F, Cl, Br, lower alkyl having from 1 to 5 carbon atoms, lower alkoxy having from 1 to 5 carbon atoms, alkylenedioxy having from 1 to 3 carbon atoms, -CF3 or -CN substituents, R1-R4 are independently H, CH3, C2H5 with cis or trans configuration provided that only two of them are other than hydrogen, and pharmaceutically acceptable salts thereof are described. Processes for their preparation are also described. The compounds are useful for treatment of mental disorders, such as aggression and psychosis in mammals.

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