1-propanol and 1-propylamine derivatives and their use as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/233 (2006.01) A61K 31/403 (2006.01) A61K 31/4375 (2006.01) A61K 31/4412 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61K 31/54 (2006.01) A61K 31/551 (2006.01) C07D 209/00 (2006.01) C07D 211/74 (2006.01) C07D 213/68 (2006.01) C07D 241/04 (2006.01) C07D 241/42 (2006.01) C07D 243/06 (2006.01) C07D 265/00 (2006.01) C07D 279/10 (2006.01) C07D 295/08 (2006.01) C07D 401/02 (2006.01) C07D 405/06 (2006.01) C07D 413/02 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2512257

Compounds of Formula (I) wherein R1, R2 R3, R4, R5, R6, and X are as defiend herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocoricoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

La présente invention a trait à des composés de formule (I), dans laquelle R?1¿, R?2¿ R?3¿, R?4¿, R?5¿, R?6¿, et X sont tels que définis dans la description pour la formule (IA) et la formule (IB), ou un tautomère, un prodrogue, un solvate, ou un sel de ceux-ci ; des compositions pharmaceutiquement acceptables contenant de tels composés, et des procédés de modulation de la fonction du récepteur de glucocorticoïde et des procédés de traitement de maladie ou des conditions médiées par la fonction du récepteur de glucocorticoïde ou caractérisées par des processus inflammatoires, allergiques, ou proliférants chez un patient utilisant ces composés.

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