1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as...

Details 1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as... 1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2244136

The invention concerns new 1-pyrazol-3-yl-ethyl-4-indol-3-piperidine derivatives of formula (I) where R1 is H or A; R2 is H, a phenyl substituted 1 to 3 times by Hal, NO2, CON(R4)2, SO2N(R4)2, cyanogen, A or R4-O; R3 is H, Hal, A, A-O-, amino, cyanogen, carboxamide, NO2, SO2N(R4)2; R4 is H or A; A is (C1-C6)alkyl or (C1-C6)alkyl containing one to three times substituted by fluorine; Hal is F, Cl, Br or J. The invention also concerns the salts of said derivatives. It has been shown that these compounds have an interesting pharmaceutical activity.

L'invention concerne de nouveaux dérivés de la 1-pyrazol-3-yléthyl-4-indol-3-pipéridine, de formule (I), où R?1¿ est H ou A; R?2¿ est H, phényle 1 à 3 fois substitué par Hal, NO¿2?, CON(R?4¿)¿2?, SO¿2?N(R?4¿)¿2?, cyano, A ou R?4¿-O; R?3¿ est H, Hal, A, A-O-, amino, cyano, carboxamide, NO¿2?, SO¿2?N(R?4¿)¿2?; R?4¿ est H ou A; R?5¿ est H ou A; A est alkyle contenant 1 à 6 atomes de carbone ou alkyle contenant 1 à 6 atomes de carbone et 1 à 3 fois substitué par fluor; Hal est F, Cl, Br ou J. L'invention concerne également les sels desdits dérivés. On a découvert que ces substances ont une activité pharmaceutique intéressante.

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