1-(pyridinylalkyl)-1h-indoles, indolines and related analogs

Details 1-(pyridinylalkyl)-1h-indoles, indolines and related analogs 1-(pyridinylalkyl)-1h-indoles, indolines and related analogs

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2048980

1-(Pyridinylalkyl)1-H-indoles, indolines and related analogs This invention relates to compounds of the formula <see formula I> wherein R1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl; P2 is hydrogen, lowralkyl, loweralkenyl, formyl or cyano; X is hydrogen, halogen, vitro, amino, loweralkyl, loweralkoxy or hydroxy; Y is hydrogen, loweralkyl, loweralkoxy, arylloweralkoxy, hydroxy, halogen, vitro or amino; the pharmaceutically acceptable acid addition salts thereof, and, where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.

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