1-(pyridinylamino)-2-pyrrolidinones, a process for their...

Details 1-(pyridinylamino)-2-pyrrolidinones, a process for their... 1-(pyridinylamino)-2-pyrrolidinones, a process for their...

C - Chemistry, Metallurgy

07

D

167/231, 260/278

C07D 401/12 (2006.01) A61K 31/44 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2022484

This invention relates to 1-(pyridinylamino)-2-pyrrolidinones of the formula (see formula I) wherein R1, R2 and R3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl or R2 and R3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl or heteroaryl cycloalkane; X is halogen, hydroxy, loweralky, loweralkoxy, nitro, amino or trifluoromethyl; m is zero or an integer of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometrical, optical and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics, for enhancing memory and for the treatment of Alzheimer's disease.

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