1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1h-indoles,...

Details 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1h-indoles,... 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1h-indoles,...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/535 (2006.01) A61K 31/5383 (2006.01) A61K 31/55 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2065986

This invention relates to compounds of the formula (see formula I) wherein R1 is hydrogen or loweralkyl; R2 is hydrogen or loweralkyl; and R3 is hydrogen, loweralkyl, halogen, nitro, amino, hydroxy, loweralkoxy, benzyloxy or Image where R4 is hydrogen or loweralkyl and R5 is loweralkyl, aryl or arylloweralkyl, or R4 and R5 taken together form a heterocyclic ring selected from the group consisting of Image wherein R6 is hydrogen, loweralkyl, aryl or arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof. the compounds of this invention are useful for alleviating depression and various memory dysfunctions characterized by a cholinergic or adrenergic deficit, such as Alzheimer's Disease, and can, therefore, be used as medicaments.

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