1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indol...

Details 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indol... 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indol...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 403/14 (2006.01) C07F 9/572 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2409367

The present invention is directed to 1-pyrrolidin-1-ylmethyl-3-(pyrrol-2- ylmethylidene)-2-indolinone derivatives of the formula that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

L'invention concerne des dérivés de 1-pyrrolidin-1-ylméthyl-3-(pyrrol-2-ylméthylidène)-2-indolinone qui modulent l'activité de protéines kinases (PK). L'invention concerne en outre des compositions pharmaceutiques qui contiennent ces composés, des méthodes de traitement de maladies liées à une activité anormale de PK, reposant sur l'utilisation de ces compositions, ainsi que des procédés de préparation de ces dernières.

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