¬1'(s),5's|hexahydro-1'-(3-sulfur containing-2-...

Details ¬1'(s),5's|hexahydro-1'-(3-sulfur containing-2-... ¬1'(s),5's|hexahydro-1'-(3-sulfur containing-2-...

C - Chemistry, Metallurgy

07

D

167/231, 167/233

C07D 491/113 (2006.01) A61K 31/40 (2006.01) C07D 491/10 (2006.01) C07D 495/10 (2006.01)

Patent

CA 1263657

HA286 ABSTRACT ACYLMERCAPTOALKANOYL AND MERCAPTOALKANOYL SPIRO COMPOUNDS The present invention provides new acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds of the formula (I) Image and pharmaceutically acceptable salts thereof, wherein: X is oxygen or sulfur; R is hydrogen, lower alkyl, or a salt forming ion; R1 is hydrogen, lower alkyl, or trifluoromethyl; R2 is hydrogen or Image ; R3 is lower alkyl, Image Image or Image and n is zero or an integer from 1 to 4. These new compounds possess angiotensin converting enzyme inhibition activity and are thus useful as anti-hypertension agents.

453578

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