1-secondary amino-3-substituted phenoxy-propan-2-ols and...

Details 1-secondary amino-3-substituted phenoxy-propan-2-ols and... 1-secondary amino-3-substituted phenoxy-propan-2-ols and...

C - Chemistry, Metallurgy

07

C

260/470.1, 260/4

C07C 275/24 (2006.01)

Patent

CA 1088557

ABSTRACT OF THE DISCLOSURE 1-Isopropylamino-3-(4- or 2,4-substituted phenoxy)-propan-2- ols of the formula Image wherein R1 is loweralkyl, R2 is mono(lower)alkylcarbamoylaminoethyl, di- (lower)alkylcarbamoylaminoethyl, carbamoyloxy(lower)alkyl, mono(lower)alkyl- carbamoyloxy(lower)alkyl, di(lower)alkylcarbamoyloxy(lower)alkyl, carbamoyl- oxy(lower)alkoxy, mono(lower)alkylcarbamoyloxy(lower)alkoxy or di(lower)alkyl- carbamoyloxy(lower)alkoxy, and R3 is hydrogen or halogen; are described as new compounds possessing valuable pharmacological properties. They block cardiac and vascular .beta.-receptors and can be used as cardioselective anta- gonists of adrenergic .beta.-receptor-stimulators, e.g. in the treatment of ar- rhythmias and angina pectoris. A process for the preparation of the new compounds is also described.

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