1-¬styryl|- and 1-¬2'-(heteroaryl) -ethenyl| -isoquinoline...

Details 1-¬styryl|- and 1-¬2'-(heteroaryl) -ethenyl| -isoquinoline... 1-¬styryl|- and 1-¬2'-(heteroaryl) -ethenyl| -isoquinoline...

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 217/14 (2006.01) C07D 217/16 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2148412

The invention relates to anxiolytic pharmaceutical compositions comprising as active ingredient 1-styryl- isoquinoline derivatives of general formula (I), wherein n is 1, 2, 3 or 4; R may be the same or different and represent(s) hydrogen, lower alkyl, lower alkoxy or hydroxy, or two substituents R attached to adjacent carbon atoms may form together an alkylenedioxy group; R1 represents hydrogen or lower alkyl, and Ar stands for an optionally substituted aryl or heteroaryl, Some of the compounds of general formula (I) is known, but the majority thereof has not so far described in the literature. The invention also encompasses the preparation of the new compounds of general formula (I), which comprises reacting a compound of general formula (II) with an aldehyde of general formula (III) in the presence of a condensing agent or an acidic catalyst.

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