1-substituted-1-aminomethyl-cycloalkane derivatives...

Details 1-substituted-1-aminomethyl-cycloalkane derivatives... 1-substituted-1-aminomethyl-cycloalkane derivatives...

C - Chemistry, Metallurgy

07

D

C07D 291/04 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61K 31/662 (2006.01) A61P 25/00 (2006.01) C07C 233/36 (2006.01) C07C 239/14 (2006.01) C07C 259/06 (2006.01) C07C 309/25 (2006.01) C07C 311/05 (2006.01) C07C 311/07 (2006.01) C07C 311/09 (2006.01) C07C 311/10 (2006.01) C07C 311/33 (2006.01) C07D 257/04 (2006.01) C07D 271/06 (2006.01) C07D 271/07 (2006.01) C07D 285/08 (2006.01) C07D 285/18 (2006.01) C07F 9/38

Patent

CA 2304974

Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; A' is a bridged ring selected from (1), (2), (3), (4), (5) wherein is the point of attachment; Z1 to Z4 are each independently selected from hydrogen and methyl; o is an integer of from 1 to 4; and p is an integer of from 0 to 2. In formula (1) above R cannot be sulfonic acid when m is 2 and n is 1 are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammatory diseases, and gastrointestinal disorders, especially irritable bowel syndrome.

L'invention concerne des nouvelles amines de formules 1, 1C, 1F, 1G et 1H, ou un sel pharmaceutiquement acceptable de celles-ci. Dans lesdites formules, n vaut un entier de 0 à 2; m vaut un entier de 0 à 3, R représente sulfonamide, amide, acide phosphonique, hétérocycle, acide sulfonique ou acide hydroxamique; A' est un cycle ponté choisi parmi (1), (2), (3), (4) et (5), étant le point d'attache, Z1 à Z4 représentant chacun séparément hydrogène ou méthyle; o vaut un entier de 1 à 4; et p vaut un entier de 0 à 2. Dans la formule 1, R ne peut représenter acide sulfonique lorsque m vaut 2 et n vaut 1. Lesdites amines et ledit sel sont utiles en tant qu'agents de traitement de l'épilepsie, des crises de lipothymie, de l'hypocinésie, de troubles crâniens, de troubles neurodégénératifs, de la dépression, de l'anxiété, de la panique, de la douleur, de troubles neuropathologiques, d'affections inflammatoires et de troubles gastro-intestinaux, notamment du syndrome du côlon irritable. Des procédés de préparation et des nouveaux intermédiaires utiles dans la préparation sont également décrits.

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