1-substituted-3,4-epoxypyrrolidines

C - Chemistry – Metallurgy – 07 – D

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260/298.5

C07D 491/044 (2006.01) C07D 207/20 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1135701

ABSTRACT OF THE INVENTION 3,4-Epoxypyrrolidines substituted in the 1-position with alkyl, cycloalkyl and phenylalkyl are disclosed which have pharmaceutical application in cataract prevention in animals and as intermediates in preparation of trans-3- aryloxy-4-hydroxypyrrolidines. The epoxypyrrolidines are prepared by a novel route involving chlorination of pyrrolines in aqueous medium.

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