1-substituted-3-arylthio-4-hydroxypyrrolidines

Details 1-substituted-3-arylthio-4-hydroxypyrrolidines 1-substituted-3-arylthio-4-hydroxypyrrolidines

C - Chemistry, Metallurgy

07

D

260/325

C07D 207/12 (2006.01) C07D 207/20 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1133912

ABSTRACT OF THE INVENTION Trans isomers of 1-substituted-3-arylthio-4- hydroxypyrrolidines and derivatives thereof having the formula: Image are disclosed wherein R1 is hydrogen, lower-alkyl, -C(O)NH-lower-alkyl and -C(O)-NH-phenyl; R2 is lower- alkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.

343330

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