1-substituted-4-(1,2-diphenylethyl)piperazine derivatives...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/00 (2006.01) C07D 295/03 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1051433

1-SUBSTITUTED-4-(1,2-DIPHENYLETHYL)- PIPERAZINE DERIVATIVES AND THEIR SALTS AND THE PREPARATION THEREOF Abstract of the Disclosure: 1-Substituted-4-(1,2-diphenylethyl)piperazine deriv- atives of the formula: Image [I] wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl, and their pharmaceutically acceptable salts, which have ex- cellent analgesic, anti-tussive and anti-inflammatory activi- ties, without undesirable side effect such as narcotic activ- ity, and a process for the preparation thereof. - 1 -

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