1-substituted-4-benzylidenepiperidines

Details 1-substituted-4-benzylidenepiperidines 1-substituted-4-benzylidenepiperidines

C - Chemistry, Metallurgy

07

D

260/292.2

C07D 211/70 (2006.01)

Patent

CA 1072562

AHR-282 1-SUBSTITUTED-4-BENZYLIDENEPIPERIDINES ABSTRACT OF THE INVENTION Novel 1-substituted-4-benzylidene piperidines useful as antiinflammatory agents and tranquilizers are represented by the formula Image wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkyl, carbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N- arylcarbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbonyl; R1 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R1 is phenyl, R is other than aroyl- loweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.

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