1-substituted-4-benzylpiperidines

Details 1-substituted-4-benzylpiperidines 1-substituted-4-benzylpiperidines

C - Chemistry, Metallurgy

07

D

260/278.1, 260/2

C07D 211/08 (2006.01) C07D 211/12 (2006.01) C07D 211/14 (2006.01) C07D 211/16 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/32 (2006.01)

Patent

CA 1059512

ABSTRACT OF THE INVENTION Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as antiinflammatory agents, sedatives, and tranquilizers are represented by the formula Image wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkyl- carbamoyl, N-lower-alkylcarbamoyl, N,N,-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower- alkylcarbamoyl, N-(.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o- methoxyphenoxy)propyloxycarbamoyl, 2-carbamoylethyl, or 4-(p- fluorobenzoyl)piperidionoethyl; R1 represents hydrogen or hydroxy; R2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R2 is phenyl, R is other than aroyl- loweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of formula I are included as part of the invention.

241425

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