1-substituted-7-(beta-d-glycopyranosyloxy)(aza)indole...

Details 1-substituted-7-(beta-d-glycopyranosyloxy)(aza)indole... 1-substituted-7-(beta-d-glycopyranosyloxy)(aza)indole...

C - Chemistry, Metallurgy

07

H

C07H 17/02 (2006.01) A61K 31/7056 (2006.01) A61K 45/00 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/48 (2006.01) A61P 7/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 19/06 (2006.01)

Patent

CA 2597269

[PROBLEMS] To provide a compound having SGLT1 and/or SGLT2 inhibiting potency that can be used as a preventive or therapeutic agent for diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complication, obesity, etc. [MEANS FOR SOLVING PROBLEMS] There are provided 1-substituted-7- (.beta.-D-glycopyranosyloxy)(aza)indole compounds of the general formula (I), prodrugs or pharmacologically acceptable salts thereof, and hydrates or solvates thereof. [Chemical formula 1] (I) wherein R1 is a halogen atom, etc.; n is an integer of 0 to 3; R2 is a halogen atom, etc.; X is a nitrogen atom or carbon atom having a hydrogen atom, etc. bonded thereto; Q is an alkenylene group or alkylene group optionally having an oxygen atom or sulfur atom in its chain; and A is an optionally substituted aryl or heteroaryl group.

Le problème à résoudre dans le cadre de cette invention consiste à procurer un composé possédant une action inhibitrice vis-à-vis de SGLT1 et/ou SGLT2 pouvant être utilisé en tant qu~agent de prévention ou agent thérapeutique pour le diabète, l~hyperglycémie postprandiale, l'altération de la tolérance au glucose, les complications diabétiques, l~obésité, etc. La solution proposée consiste en des composés 1-substitués-7-(.beta.-D-glycopyranosyloxy)(aza)indole de formule générale (I), des promédicaments ou sels pharmacologiquement acceptables de ceux-ci, ainsi que des hydrates ou solvates de ceux-ci. [Formule chimique 1] (I) où R1 est un atome d~halogène etc.; n est un nombre entier entre 0 et 3; R2 est un atome d~halogène, etc.; X est un atome d~azote ou un atome de carbone possédant un atome d~hydrogène, etc. qui y est lié; Q est un groupe alkénylène ou alkylène ayant facultativement un atome d~oxygène ou un atome de soufre dans sa chaîne; et A est un groupe aryle ou hétéroaryle facultativement substitué.

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