1'-substituted carba-nucleoside analogs for antiviral treatment

Details 1'-substituted carba-nucleoside analogs for antiviral treatment 1'-substituted carba-nucleoside analogs for antiviral treatment

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/4188 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2722177

Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Formula (I), each X1 or X2 is independently C-R10 or N.

Linvention concerne des nucléosides de pyrrolo[1,2-f][1,2,4]triazinyle, imidazo[1,5-f][1,2,4]triazinyle, imidazo[1,2-f][1,2,4]triazinyle, et [1,2,4]triazolo[4,3-f][1,2,4]triazinyle, des phosphates nucléosidiques et des promédicaments de ceux-ci, où la position 1 du sucre du nucléoside est substituée. Les composés, compositions et procédés fournis sont utiles pour le traitement de virose de Flaviviridae, en particulier des infections à lhépatite C. Dans la formule (I), chaque X1 ou X2 est indépendamment C-R10 ou N.

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